Tuesday, May 14, 2013

Bring Back the Mind

*Please note that this is not written by a qualified physician. Please see your doctor before trying anything suggested here.*

We are plagued by mental disorders. Alzheimer's is the 6th leading cause of death in the US. More than one million Americans suffer from Parkinson's. All in all, about 26.2% of adults in America have a mental disorder of some sort. But what if we could cure them and reverse them using stem cells?

List of Mental Diseases. The more people it affects, the larger the text. Image Credit: alzcare.org
There are some promising studies for Alzheimer's, Parkinson's, and other disorders. However, we need to dig into some philosophical issues first to see if this is even possible.

Imagine that you have a ship (we'll call this ship #1), and that you are asked to build the same ship. You measure all the dimensions and using new planks, build an exact replica (ship #2). The question: Is ship #2 a different thing than ship #1? We'd probably say yes.

Now imagine that you have ship #1, and rip out a few old planks and replace them with new ones. You rip some more out, and replace. You continue to do this until you have replaced all the planks with new ones. The question: Is the ship the same thing as it was before?

This is called the Ship of Theseus Paradox and has been debated for years. How does this relate to mental disorders? Imagine each plank represents a neuron. With age and diseases, you may need to "rip out" some of these malfunctioning neurons and replace them with new ones (stem cells).

The point is that it is not the physical matter that makes us special. It is the way it is organized. The design of our brain is what is important, not the actual atoms that make it up. Atoms can always be replaced: design can't be.

This clarifies what stem cells could do. When you have a neurodegenerative disorder, your neurons die, and are gone. The saddest part though is that the design is lost with them.

But there is hope. When we learned to walk, we had to organize our neurons so that we could walk. When dogs (who have lost the ability to walk) are implanted with stem cells, they too again have to learn have to walk. Stem cells are the physical matter, and with training, we can organize them properly. We can restore the design by learning.

This means that your grandpa and grandma may have lost their smarts. However, with stem cells, they can re-learn them. In fact, not only could they re-learn them, but they could also get better because they have fresh neurons to tackle the problem.

© Nicholas Shah and Learning More Than Living, 2013. Please note that the material included this was not written by a licensed medical professional. Therefore, please consult your physician before trying anything suggested in this article. Please note that there was an image used from alzcare.org. This blog does not claim ownership of that image. Nicholas Shah does not claim ownership to the ideas put forth here. Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to Nicholas Shah and Learning More Than Living with appropriate and specific direction to the original content. Thank You. 

2 comments:

  1. I might have lost a few neurons while reading this, good thing I'll be able to replace them...

    1.I personally would recommend to stop linking to wikipedia:

    a. It looks lazy and unprofessional.

    b. It is near the top of the page of a google search if the reader really needs background.

    c.NIH has a much nicer site in this case: http://www.nlm.nih.gov/medlineplus/alzheimersdisease.html

    2. Put aside the philosophy for a moment, and consider the facts. Due to the pathophysiology of Alzheimer's this may not be as promising as you claim as adding new tissue does nothing to correct the problems of amyloid plaques and neurofibrillary tangles.

    3. DO NOT use sources from treachertorious sensationalist reporting sites (pretty much anything involving .co.uk)! READ the full article it pitifully attempts to describe:
    http://www.nature.com/nature/journal/v480/n7378/full/nature10648.html

    The article brings up some serious issues such as the dangers of treatment and the ongoing issues of correlation between the model animals and humans.

    4. DO NOT use sources from treachertorious sensationalist reporting sites (pretty much anything involving .co.uk)! READ the full article it pitifully attempts to describe: http://brain.oxfordjournals.org/content/135/11/3227.full

    The dogs were not implanted with stem cells. It was autologous olfactory mucosal cell transplants containing a mean of ∼50% olfactory ensheathing cells. While some cells in the olfactory mucosal region can display some plasticity, nowhere in the paper are stem cells even mentioned, and the treatment focused on using existing neurons and glia supporting cells to repair damage.

    5. First a little background: My grandmother has dementia. She does not remember who I am. She wants to move back to her home the she sold years ago, and believes she has been in the nursing home she has lived in for years for only a few months.

    She may have lost her smarts. However, she'll be deceased before the problems of creating a neural network with exogenous cells are solved as we have little data that your naive optimism has any practical clinical value.

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  2. 5 things to THINK about...

    1. Wikipedia is a good go-to source for quick information about a new topic.
    a. At least he bothered to link it.

    b. Why make the reader do more work?

    c. Wikipedia has more information and links than the NIH site.

    2. This does show promise of fixing the increased insulin resistance in the brain and neuron degeneration seen in Alzheimer’s.

    3. Treachertorious isn’t a word, and safety will be carefully monitored and developed as better models are.

    4. It still offers proof-of-concept that new neuronal connections can be made functional.

    5. I’m sorry about your grandmother. Mine is like that as well. You are not alone. This offers some hope someday, and there is no need to be so cynical.

    -ARGotI

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